Product Description
Bortezomib is a proteasome inhibitor and antineoplastic agent that is used in treatment of multiple myeloma (a type of cancer of the bone marrow) and cell lymphoma (a fast-growing cancer that begins in the cells of the immune system). Bortezomib reversibly inhibits the 26S proteasome, a large protease complex that degrades ubiquitinated proteins. By blocking the targeted proteolysis normally performed by the proteasome, bortezomib disrupts various cell signaling pathways, leading to cell cycle arrest, apoptosis, and inhibition of angiogenesis. Specifically, the agent inhibits nuclear factor (NF)-kappaB, a protein that is constitutively activated in some cancers, thereby interfering with NF-kappaB-mediated cell survival, tumor growth, and angiogenesis. In vivo, bortezomib delays tumor growth and enhances the cytotoxic effects of radiation and chemotherapy.
